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Our Portfolio Companies to Date

1. ActX, Inc. (2017) (www.actx.com) ActX is a Seattle-based company focused on Actionable Genomics℠: evidence-based genetic risks that you can do something about, whether it is a medication affected by genetics, or a medical genetic risk such as a specific cancer risk. ActX is a continuous service — the analysis provided is frequently updated based on the latest evidence.

2. Advanced Liquid Logic, Inc. (2007, 2008, 2009)- successful exit in July 2013 which saw the acquisition of Advanced Liquid Logic (ALL) by Illumina, Inc. (www.liquid-logic.com) and (www.illumina.com) – ALL is now a wholly owned subsidiary of Illumina Inc., a San Diego based and NASDAQ listed company which makes genetic testing tools. ALL’s proprietary "digital microfluidics" often referred to as “Lab on a Chip diagnostics” was attractive to Illumina for the development of their next generation gene sequencing. ASAP’s investments enabled ALL to develop its innovative technology to an impressive and proven level. The technology electrically segments and manipulates small droplets within a sealed disposable cartridge to perform complex laboratory protocols on fluids such as blood, sewage, water, chemicals and solutions.

3. AG - TI, LLC. (2014) (www.AGTI.com) AG-TI is a spin out company from our STI investment. It is focused on the agricultural technology and food production systems space and using an expedited strategic partnership model for growing and exiting companies.

4. AMPLYX Pharmaceuticals, Inc. (2011) (www.amplyx.com) Amplyx Pharmaceuticals, Inc. is a preclinical stage company focusing on the development of small molecule drugs with enhanced efficacy and lower toxicity. Amplyx employs a platform approach to improve small molecule drugs by the addition of a second small molecule to an existing drug with initial development areas are in oncology and infectious disease.

5. Bioptigen, Inc. (2008, 2009) (www.bioptigen.com) Bioptigen’s proprietary Envisu™ Spectral Domain Ophthalmic Imaging Systems (SDOIS) use low powered near infrared light to generate depth-resolved images of ocular tissue structures, non-invasively and in real-time. (Sold to Leica Microsystems 2015)

6. Carmell Therapeutics, Inc. (2011, 2014, 2016) (www.carmellrx.com) Carmell is a Pittsburgh, PA firm that is commercializing technology that enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue.

7. Carrot Medical, Inc. (2010) (www.carrotmedical.com) A Seattle integrator of multiple independent diagnostic and procedural imaging sources and patient monitoring systems in simultaneous use during medical procedures. Consolidating information into fewer redundant monitors and displays increases the availability of clinically relevant, real-time data of to the clinical decision-maker, and optimizes space, patient care and economic efficiency.

8. Cognition Therapeutics, Inc. (2014, 2016) (www.cogrx.com) Cog RX is pursuing a unique process for the early detection of Alzheimer’s disease with a potential to treat and reverse the disease.

9.  Consortia TX, Inc. (2017) Consortia TX is a biopharmaceutical company that focuses on therapies of human colonizing microbes and microbial products to treat human diseases. The company's first patented consortia have been developed for the prevention and treatment of human food allergies. Other applications are in process.

10. Decision Link, Inc. (2014, 2016) (www.decisionlink.com) A business intelligence sales software system for improving the content packaging of relevant product information and performance evaluation data for justifying the use of systems products in an operational customer setting. Focused on improving the sales closing rates of sales professionals.

11. Embera NeuroTherapeutics, Inc.  (2014, 2016) (www.emberaneuro.com) EMBERA is an early stage drug development company that is testing a unique compounding of two existing drugs for the purpose of controlling smoking cessation and drug addiction.

12. FAST Biomedical (2009, 2014, 2015) (www.fastbiomedical.com) An Indianapolis, IN company with a revolutionary new point-of-care system for accurate, sensitive and rapid measurement of kidney function, which is revolutionary in the diagnosis of Acute Kidney Injury.

13.  HelixBind, Inc. (2017) (www.helixbind.com) HelixBind is a Massachusetts based company focused on its patent pending Pathogen Identification (PID) platform that will provide rapid detection and unequivocal identification of bloodstream infections, direct from a whole blood specimen and without the need for blood culture. This will allow physicians to quickly adjust to the optimal, targeted, antimicrobial intervention and monitor the effectiveness of that treatment throughout care.

14.  LaunchPad Medical (2017) (www.launchpadmedical.com) LaunchPad Medical is an early-stage medical device company that was formed to develop and commercialize Tetranite™, which is a novel bioresorbable bone adhesive technology co-invented by the CEO. The Massachusetts based company aims to develop and manufacture products based on this patented technology. The first product developed from this platform technology is designed for use within the field of implant dentistry.

15.  Mellitus (2017) (www.mellitusllc.com) Mellitus is a Boston-based company dedicated to advancing diabetes detection and monitoring through products based on GCD59, a biomarker of glycemic load that is unique because of its direct relationship to the complications of diabetes. The company’s premier application is a patient-friendly test for gestational diabetes, enabling more timely intervention to improve the health of both mother and child.

16. Monitor Mask, Inc. (2016) (www.monitormask.com) Monitor Mask is a Bellevue, Washington medical device company founded with the mission of creating capnography oxygen face masks to increase patient safety and streamline workflows. The first design, the M1 Capnography Mask, was imagined in the spring of 2011 and served as the inspiration for the CapnoVue face mask series. CapnoVue devices facilitate capnography in medical practice, increase patient safety, make care workflows more efficient, and help clinicians meet monitoring standards.

17. NeurOP, Inc. (2007, 2009, 2011) (www.neuropinc.com) NeurOp, Inc. is a biopharmaceutical company developing new medicines to treat central nervous system disorders, including major depression, neuropathic pain and ischemia. Our mission is to develop a new generation of N-methyl-D-aspartate (NMDA) receptor blockers, which inhibit proteins that play an important role in neuron signaling. Our compounds specifically target the NR2B subtype of these receptors offering an unprecedented opportunity to improve the safety and tolerability of this therapeutic class without compromising efficacy.

18. New View Surgical (2018) (www.newviewsurg.com) With an in-depth understanding of minimally invasive surgery, the New View Surgical team has embarked on a mission to improve the outcomes and efficiency of laparoscopic surgical procedures through the introduction of our VisionPort™ technology. The company’s innovative VisionPort™ technology combines four devices (the laparoscope, camera, light source and access port) into one, providing the surgeon with complete control of both visualization and instrumentation, and enhancing the efficiency of the entire surgical team. New View Surgical is headquartered in Boston, Massachusetts.

19. New Wave Surgical (2010, 2011) (www.newwavesurgical.com) New Wave Surgical Corp. (NWS) is a premier medical device development company working to design, patent and market medical devices for laparoendoscopic surgical markets. Our first exciting innovation was D-H.E.L.P.®–the only endoscopic visualization system that keeps the laparoscopic lens defogged and clean from the start of surgery to close. NWS was acquired by Covidien, Inc. in a cash buyout in July 2014.

20. NorthShore Bio (2015, 2016) (www.northsorebio.com) NorthShore Bio is a life sciences tools and services company that focuses on the development of direct-to-digital™ nanopore chips, instrumentation appliances, and low-cost sequencing services that enable a range of tests, from simple to data-rich, making sequencing faster, simpler, and more accessible to researchers, clinicians, and field practitioners. NSB's platform changes the "molecular information" problem with the development of proprietary silicon-based, label-free direct electrical sensors that enable significant advances in the resolution and speed of molecular measurement. For example, the chip's proprietary silicon nanopores can be tuned, or sized, electronically to dimensions that will allow for selective identification of DNA, RNA, small molecules, and ion flow.

21. Optima Neuroscience (2010) (www.optimaneuro.com) A Gainesville, FL medical device company producing a line of revolutionary brain monitoring products designed for use in hospital intensive care units and emergency rooms. The unit is a wearable head cap with built-in sensors couples to a monitor with software that can predict possible stroke events and provide early warning for proactive intervention. (Optima Neuroscience was acquired by its key distributor in a cash buyout in 2011.)

22. OrthoPediatrics, Inc. (2009) (www.orthopediatrics.com)– OrthoPediatrics is the first company whose total focus is helping children with orthopedic conditions and injuries by providing the surgeons who care for them with anatomically appropriate implants.  The company completed an IPO in 2017.

23. R and R Music, Inc. (2009, 2010) (www.randrmusic.com) (Originally Music Intelligence Solutions, Inc.) A Savannah, GA company with operations in CA and Spain with IP to predict a new music pieces success potential of becoming a hit. Scores and compares music to a deductive universe of prior hits. Now actively selling a rating service to the music writing industry that couples to an on-line marketing and distribution service for high scoring music products. Merger moved operations to Scotland, UK.

24. Respiratory Motion (2012, 2014, 2016) (www.respiratorymotion.com) -Respiratory Motion, Inc. (RMI) is a new generation medical device company developing and commercializing the ExSpironTM. a noninvasive, continuous respiratory monitor which has received FDA clearance to graphically display lung volumes against time in a wide variety of patients, which more adequately predicts ventilatory distress and cost-effectively improves the standard of care in respiration monitoring.

25.  SafKan, Inc.  (2018) (www.safkanhealth.com) SafKan, Inc. is a Seattle-based medical device company that has created the SafKan OtoSet for clinical ear care. Every week 231,000+ Americans have their ears cleaned by physicians. The SafKan OtoSet is the first automated and wearable cerumen removal device. The device is designed to reduce complications such as hearing loss, lacerations, and membrane perforation and can be used by any healthcare professional.

26. Southeast TechInventures, Inc. (2007, 2009, 2010) (www.southeasttechinventures.com) Located in Durham, NC, STI mission is to build an effective and profitable technology accelerator for rapid conversion of scientific breakthroughs into products, services and new technology companies. STI partners with inventors to accelerate the commercialization of technologies and intellectual property (IP). Our current focus areas include medical devices, diagnostics, biotechnology, nanotechnology, materials, electronics, and agriculture including agricultural biotechnology.

27. Standard Bariatrics, Inc. (2018) (www.standardbariatrics.com) Standard Bariatrics, Inc., is a Cincinnati-based surgical procedure company focused on the innovative development and commercialization of medical devices for the surgical treatment of obesity. Driven by a passionate group of surgical innovators, the company will continue to release surgical solutions designed to address the growing global epidemic of obesity. The Standard Bariatrics management team has over 175 combined years of experience in developing and commercializing novel medical device technologies with a record of achieving both clinical and economic excellence for patients and providers.

28. Virginia Distillery Company (2010) (www.VADistillery.com) A Dixon Country, VA niche producer and marketer of high-end malt liquor to be made in a new Virginia distillery with single and double malt products.